Abstract: Recent remarkable progress in the field of sub-Angstrom high-resolution electron microscopy (HRTEM) is briefly reviewed. In particular, it is shown that numerous important structural issues can now be studied with the arrival of this kind of advanced HRTEM in laboratories. Sub-angstrom HRTEM could significantly promote the development of crystallography, material science, physics, nano-materials and biology. The typical new generation HRTEM facility, equipped with Cs-corrector and monochromator, will give us high-quality atomic HRTEM images with a resolution better than 1, and also high resolution electron energy loss spectra with a resolution better than 0.1eV.