Abstract: On the occasion of the 80th anniversary of the Institute of Physics we present a brief introduction to the recent progress in our research on biological soft matters in the Laboratory of Soft Matter Physics, including single-molecule studies of DNA, the interaction dynamics between DNA and histones, the mechanism of biological molecular motors, the DNA binding and unwinding kinetics of helicases, molecular dynamics investigations on the aggregation of prion fragments, T-jump/time-resolved spectroscopy of protein folding dynamics, and studies on the topological shape of integral membrane protein light-harvesting complexes from photosynthetic bacteria.