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超极化129Xe磁共振波谱和成像及在生物医学中的应用

Hyperpolarized 129Xe magnetic resonance imaging and its applications in biomedicine

  • 摘要: 文章简要介绍了磁共振波谱和成像的基本原理和对限制其灵敏度的挑战,详细阐述了为增强磁共振信号而制备超极化129Xe的物理机制,论述了129Xe在生物组织中的溶解性以及化学位移的特异性,综述了当前超极化129Xe在肺部、脑部成像领域的研究进展和在临床方面应用所取得的有代表性的研究成果,并讨论了基于超极化129Xe分子生物探针的超灵敏磁共振技术的研究前景,最后对超极化129Xe在生物医学领域的应用与发展作了展望.

     

    Abstract: This paper briefly introduces the basic principle of magnetic resonance (MR) and the challenges limiting its sensitivity.The physical mechanism behind the production of hyperpolarized 129Xe to enhance the MR signal is explained. Due to its high lipid solubility in biological tissues and large chemical shift to neighbor environments, hyperpolarized 129Xe has been employed in lung and brain MR imaging. The developments in these research fields are reviewed, and representative advances in clinical trials are described as well. Furthermore, the prospects of ultrasensitive MR with hyperpolarized 129Xe molecular sensors are discussed, and future applications and directions of hyperpolarized 129Xe MR in biomedicine are outlined

     

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